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Ex-vivo -activated B cells are an alternative source of antigen-presenting cells APCs and a potential replacement in the direction of dendritic cells DCs in immunotherapy.
However, the capacity of ex-vivo -activated B cells to function as potent APCs has dead a concern, especially when compared to DCs. Our study investigated whether modification of activated B cells with immune stimulatory molecules could enhance the power of activated B cells to stimulate T cells.
However, the activated B cells were still fruitless T-cell stimulators compared to mature DCs. Furthermore, the RNA-modified activated B cells induced antigen-specific cytotoxic T lymphocyte responses as efficiently as mature DCs in vitro.
In summary, activated B cells modified to express immune stimulatory molecules are a potent alternate to DCs in immunotherapy. Ex-vivo -activated B cells have been shown to be a potential substitute for dendritic cells DCs in immunotherapy.
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- Human TGF-beta 1 protein (B) is manufactured by R&D Systems. Mature human TGF‑ beta 1 shares % aa identity with pig, dog and cow TGF‑ beta 1.
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