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Levonorgestrel-releasing intrauterine system LNG-IUS Lettered, although inserted to triturate heavy menstruation, causes uneven early transient bleeding. The area, density and maturation of endometrial vessels were quantified in 19 endometrial biopsies of women with LNG-IUS and in 10 normally ovulating patients as mid-luteal phase.

Vessel maturation was evaluated by dead ringer immunostaining using anti-von Willebrand factor endothelial cell marker and anti-alpha Smooth Muscle Actin vascular smooth muscle cells antibodies. Vessel district, number and density were quantified with a romance computer-assisted image analysis organization.

After long-term LNG-IUS treatment, the immature and wholly mature vessel number remained four times higher than in the control Levonorgestrel affects blood ship number, area, density and maturation in a time-dependent pattern that may spell out the early transient boost in breakthrough bleeding with the LNG-IUS.

Oxford University Press is a office of the University of Oxford.

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Levonorgestrel affects blood vessel number, area, density and maturation in a time-dependent pattern that may explain the early transient increase in breakthrough bleeding with the LNG-IUS. Several factors contribute to BTB and their down- or up-regulation is a determinant for activation and maintenance of bleeding. Perivascular smooth muscle alpha-actin is reduced in the endometrium of women with progestin-only contraceptive breakthrough bleeding.

Image analysis and vessel quantification A The contour of each type of vessel was drawn manually in the original image by the following different colours: This concept is supported by the finding that pericytes are reduced around microvessels in the endometrium of women using progestin-only contraception who suffer from BTB compared with those without BTB Rogers et al.

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